Production of J/psi, chi_c, and B-mesons at Hera-B I will discuss the results, obtained from early commissioning data taken with Hera-B in 2000, on the production of Charmonium and B-mesons in p-A interactions at 920 GeV. The present results still suffer from considerable statistical errors, caused by the fact that until now only commissioning data were available, for which not all the detector components were running. Nevertheless, the results show the encouraging systematic uncertainties which will be obtained by Hera-B in the upcoming beam period.